Search on: RIBOSOMAL PROTEIN S6 KINASES, 90-KDA 
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Descriptor English:   Ribosomal Protein S6 Kinases, 90-kDa 
Descriptor Spanish:   Proteínas Quinasas S6 Ribosómicas 90-kDa 
Descriptor Portuguese:   Proteínas Quinases S6 Ribossômicas 90-kDa 
Synonyms English:   MAP-Kinase-Activated Kinase 1
MAP-Kinase-Activated Protein Kinase 1  
Tree Number:   D08.811.913.696.620.682.700.862.500
D12.644.360.600.500
D12.776.476.600.500
Definition English:   A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN. 
History Note English:   2005(2002); for PP90(RSK) & PP90(RSK) use RIBOSOMAL PROTEIN S6 KINASES 1998-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   37342 
Unique Identifier:   D038744 

Occurrence in VHL:
 

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